Charcot-Marie-Tooth disease type 4E

Orpha code: 99951OMIM code: 605253

Definition

Charcot-Marie-Tooth disease type 4E (CMT4E) is a congenital, hypomyelinating subtype of Charcot-Marie-Tooth disease type 4 characterized by a Dejerine-Sottas syndrome-like phenotype (incl. hypotonia and/or delayed motor development in infancy), extremely slow nerve conduction velocities, potential respiratory dysfunction, cranial nerve involvement, and the typical CMT phenotype, i.e. distal muscle weakness and atrophy, sensory loss, and foot deformity.

Disease data
Classification

Disease

Synonyms
Autosomal recessive congenital hypomyelinating neuropathy
Autosomalna recesywna wrodzona neuropatia hipomielinizująca
CMT4E
CMT4E
ORPHA code
99951
OMIM code
605253
ICD10 code
G60.0
ICD11 code
-

No additional description.

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