Thanatophoric dysplasia type 2

Orpha code: 93274OMIM code: 187601

Definition

A form of thanatophoric dysplasia characterized by prenatal onset of micromelia with straight femurs, platyspondyly, narrow thorax, and cloverleaf skull with increased risk of hydrocephalus and neurological complications. Fetal MRI can identify temporal lobe abnormalities and a narrow foramen magnum. Postnatally, distinctive facial features include macrocephaly, frontal bossing, midface hypoplasia, low nasal bridge, large anterior fontanel, and proptosis. Neonates usually die shortly after birth due to respiratory insufficiency and/or spinal cord/brain stem compression.

Disease data
Classification

Clinical subtype

Synonyms
Cloverleaf skull-micromelic bone dysplasia syndrome
Czaszka w kształcie trójlistnej koniczyny - dysplazja mikromeliczna kości
Karłowatość tanatoforyczna - czaszka w kształcie trójlistnej koniczyny
Karłowatość tanatoforyczna typu 2
TD2
TD2
Thanatophoric dwarfism type 2
Thanatophoric dwarfism-cloverleaf skull syndrome
ORPHA code
93274
OMIM code
187601
ICD10 code
Q77.1
ICD11 code
-

No additional description.

Orphanet - interntowa baza danych dotyczących rzadkich chorób i sierochych leków. ©INSERM 1999 - Dostępna na stronie www.orphanet.pl