Crigler-Najjar syndrome type 2

Orpha code: 79235OMIM code: 606785

Definition

A form of Crigler Najjar syndrome (CNS), a rare hereditary disorder of bilirubin metabolism, characterized by unconjugated hyperbilirubinemia due to reduced and inducible activity of hepatic UDP-glucuronosyltransferase 1A1. The disorder clinically manifests with neonatal, isolated jaundice with a risk of developing bilirubin encephalopathy later in life due to triggers such as stress or infection.

Disease data
Classification

Clinical subtype

Synonyms
Bilirubin uridinediphosphate glucuronosyltransferase deficiency type 2
Dziedziczna niesprzężona hiperbilirubinemia typu 2
Niedobó UGT typu 2
Niedobór bilirubiny-UGT typu 2
Niedobór urydynodifosforan-glukuronosylotransferazy bilirubiny typu 2
Zespół Ariasa
Bilirubin-UGT deficiency type 2
ORPHA code
79235
OMIM code
606785
ICD10 code
E80.5
ICD11 code
-

No additional description.

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