Acute myeloid leukemia with inv(3)(q21q26.2) or t(3;3)(q21;q26.2)

Orpha code: 402020OMIM code:

Definicja

A subtype of acute myeloid leukemia with recurrent genetic abnormalities characterized by clonal proliferation of myeloid blasts in the bone marrow, blood and, rarely, other tissues. Bone marrow typically shows small, hypolobated megakaryocytes and multilineage dyslplasia. Patients typically present with leukocytosis, anemia, variable platelet counts and a variety of nonspecific symptoms related to ineffective hematopoesis (fatigue, bleeding, bruising, recurrent infections, bone pain) and/or extramedullary site involvement (gingivitis, splenomegaly). High resistance to conventional chemotherapy is reported.

Disease data
Klasyfikacja

Disease

Synonimy
AML with inv(3)(q21q26.2) or t(3;3)(q21;q26.2)
AML z inv3(p21;q26.2) lub t(3;3)(p21;q26.2)
Kod ORPHA
402020
Kod OMIM
-
Kod ICD10
C92.0
Kod ICD11
-

No additional description.

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