MiT family translocation renal cell carcinoma

Orpha code: 319308OMIM code: 300854

Definition

MiT family translocation renal cell carcinoma (t-RCC) is a rare subtype of renal cell carcinoma with recurrent genetic abnormalities, harboring rearrangements of the <i>TFE3</i> (Xp11 t-RCC) or <i>TFEB</i> [t(6;11) t-RCC] genes. The t(6;11) t-RCC has distinctive histologic features of biphasic appearance with larger epitheloid and smaller eosinophilic cells. The symptoms are usually non-specific and include hematuria, flank pain, palpable abdominal mass and/or systemic symptoms of anemia, fatigue and fever.

Disease data
Classification

Disease

Synonyms
Carcinoma associated with MITF/TFE translocation
Rak związany z translokacją MITF/TFE
Translocation renal cell carcinoma
ORPHA code
319308
OMIM code
300854
ICD10 code
C64
ICD11 code
-

No additional description.

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