Autosomal dominant hyperinsulinism due to Kir6.2 deficiency

Orpha code: 276580OMIM code: 601820

Definition

A form of diazoxide-sensitive diffuse hyperinsulinism (DHI) characterized by hypoglycemic epiosodes that are usually mild, escaping detection during infancy, and usually a good clinical response to diazoxide, (but some are diazoxide resistant). Autosomal dominant hyperinsulinism due to Kir6.2 deficiency usually has a milder phenotype when compared to that resulting from recessive K+ (K-ATP) channel mutations (Recessive forms of diazoxide-resistant hyperinsulinism).

Disease data
Classification

Disease

Synonyms
Autosomal dominant hyperinsulinemic hypoglycemia due to Kir6.2 deficiency
Autosomalna dominująca hipoglikemia hiperinsulinemiczna z powodu niedoboru Kir6.2
Dominant KATP hyperinsulinism due to Kir6.2 deficiency
ORPHA code
276580
OMIM code
601820
ICD10 code
E16.1
ICD11 code
-

No additional description.

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