Description of the disease * EnglishPolish Pobierz sekcję do PDF Definition Hereditary diffuse gastric cancer is a rare epithelial tumor of the stomach, characterized by the development of diffuse (signet ring cell) gastric cancer at a young age, associated with germline heterozygous mutations of <i>CDH1</i>, <i>MAP3K6</i> and <i>CTNNA1</i> genes. In early stages it presents with non-specific and vague symptoms, in advanced stages it may cause nausea and vomiting, dysphagia, loss of appetite, abdominal mass or weight loss. Women have an increased risk of lobular breast cancer as well. Disease data Classification Disease Synonyms FDGC Dziedziczny rozlany gruczolakorak żołądka FDGC HDGC Rodzinny rozlany rak żołądka Familial diffuse cancer of stomach Familial diffuse gastric cancer HDGC Hereditary diffuse cancer of stomach Hereditary diffuse gastric adenocarcinoma ORPHA code 26106 OMIM code 137215 ICD10 code C16.9 ICD11 code - *Soruce Extended description of the disease Pobierz sekcję do PDF No additional description. Orphanet - interntowa baza danych dotyczących rzadkich chorób i sierochych leków. ©INSERM 1999 - Dostępna na stronie www.orphanet.pl