Description of the disease * EnglishPolish Pobierz sekcję do PDF Definition A rare, genetic punctate palmoplantar keratoderma disease characterized by discrete, focal, punctate keratoderma on the palms and soles and/or slowly progressive spastic paralysis, predominantly affecting the lower limbs. Lesional histology reveals pronounced orthokeratosis, acanthosis, papillomatosis, and regular undulation to the surface keratin. There have been no further descriptions in the literature since 1983. Disease data Classification Disease Synonyms Palmoplantar hyperkeratosis-spastic paralysis syndrome Hiperkeratoza dłoni i stóp-zespół porażenia spastycznego Zespół Powella, Venencie i Gordona Powell-Venencie-Gordon syndrome ORPHA code 2201 OMIM code 148360 ICD10 code Q82.8 ICD11 code - *Soruce Extended description of the disease Pobierz sekcję do PDF No additional description. Orphanet - interntowa baza danych dotyczących rzadkich chorób i sierochych leków. ©INSERM 1999 - Dostępna na stronie www.orphanet.pl