Vitamin K antagonist embryofetopathy

Orpha code: 1914OMIM code:

Definicja

Vitamin K antagonist embryofetopathy is characterized by a group of symptoms that may be observed in a fetus or newborn when the mother has taken oral vitamin K antagonists, such as warfarin during pregnancy. Vitamin K antagonists are anticoagulant drugs that provide efficient thromboprophylaxis and that can cross the placenta. 5-12 % of infants exposed to warfarin between 6-9 weeks gestation present nasal hypoplasia and skeletal abnormalities, including short limbs and digits (brachydactyly), and stippled epiphyses. Warfarin fetopathy with central nervous system abnormalities (hydrocephalus, intellectual disability, spasticity, and hypotonia) or ocular abnormalities (microphthalmia, cataract, optic atrophy), fetal loss, and stillbirth, occurs in infants exposed at later gestations. Additional features that have been reported after in utero warfarin exposure include facial dysmorphism (cleft lip and/or palate, malformed ears), choanal atresia or stenosis, aorta coarctation, situs inversus totalis, bilobed lungs, and ventral midline dysplasia.

Disease data
Klasyfikacja

Malformation syndrome

Synonimy
Vitamin K antagonist embryopathy
Zespół di Sala
Embriopatia warfarynowa
Embriofetopatia warfarynowa
Embriopatia antagonistów witaminy K
Warfarin embryofetopathy
Warfarin embryopathy
di Sala syndrome
Kod ORPHA
1914
Kod OMIM
-
Kod ICD10
Q86.2
Kod ICD11
LD2F.02

No additional description.

Orphanet - interntowa baza danych dotyczących rzadkich chorób i sierochych leków. ©INSERM 1999 - Dostępna na stronie www.orphanet.pl