Description of the disease * EnglishPolish Pobierz sekcję do PDF Definition Autosomal recessive spastic paraplegia type 23 (SPG23) is a rare, complex type of hereditary spastic paraplegia that presents in childhood with progressive spastic paraplegia, associated with peripheral neuropathy, skin pigment abnormalities (i.e. vitiligo, hyperpigmentation, diffuse lentigines), premature graying of hair, and characteristic facies (i.e. thin with ''sharp'' features). The SPG23 phenotype has been mapped to a locus on chromosome 1q24-q32. Disease data Classification Disease Synonyms Lison syndrome Parapareza spastyczna - bielactwo nabyte - przedwczesne siwienie - charakterystyczna twarz SPG23 Zespół Lisona SPG23 Spastic paraparesis-vitiligo-premature graying-characteristic facies syndrome ORPHA code 101003 OMIM code 270750 ICD10 code G11.4 ICD11 code - *Soruce Extended description of the disease Pobierz sekcję do PDF No additional description. Orphanet - interntowa baza danych dotyczących rzadkich chorób i sierochych leków. ©INSERM 1999 - Dostępna na stronie www.orphanet.pl