Description of the disease * EnglishPolish Pobierz sekcję do PDF Definition Mal de Meleda (MdM) is a diffuse palmoplantar keratoderma, initially reported in the Island of Meleda, characterized by symmetric palmoplantar hyperkeratosis that progressively extends to the dorsal surfaces of hands and feet (transgrediens). The disease can be associated to hyperhidrosis, lichenoid plaques and perioral erythema. Disease data Classification Disease Synonyms Keratosis palmoplantaris transgrediens of Siemens Choroba Meleda Rogowiec dłoni i stóp Siemensa Transgrediens palmoplantar keratoderma of Siemens Meleda disease Transgrediens palmoplantar keratoderma of Siemens ORPHA code 87503 OMIM code 248300 ICD10 code Q82.8 ICD11 code - *Soruce Extended description of the disease Pobierz sekcję do PDF No additional description. Orphanet - interntowa baza danych dotyczących rzadkich chorób i sierochych leków. ©INSERM 1999 - Dostępna na stronie www.orphanet.pl