DPAGT1-CDG

Orpha code: 86309OMIM code: 608093

Definition

DPAGT1-CDG is a form of congenital disorders of N-linked glycosylation characterized by hypotonia, intractable seizures, developmental delay, microcephaly and severe fetal hypokinesia. Additional features that may be observed include apnea and respiratory deficiency, cataracts, joint contractures, vermian hypoplasia, dysmorphic features (esotropia, arched palate, micrognathia, finger clinodactyly, single flexion creases) and feeding difficulties. The disease is caused by loss-of-function mutations in the gene <i>DPAGT1 </i> (11q23.3).

Disease data
Classification

Disease

Synonyms
CDG syndrome type Ij
CDG1J
CDG-Ij
Niedobór fosfotransferazy dolicholofosforanu N-acetylogalaktozoaminy
Wrodzone zaburzenie glikozylacji 2j
Wrodzone zaburzenie glikozylacji IIj
Zespół CDG typu Ij
Zespół obniżonej glikozylacji glikoprotein typu Ij
CDG-Ij
CDG1J
Carbohydrate deficient glycoprotein syndrome type Ij
Congenital disorder of glycosylation type 1j
Congenital disorder of glycosylation type Ij
Dolichyl-phosphate N-acetylgalactosamine phosphotransferase deficiency
ORPHA code
86309
OMIM code
608093
ICD10 code
E77.8
ICD11 code
-

No additional description.

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