MGAT2-CDG

Orpha code: 79329OMIM code: 212066

Definition

MGAT2-CDG is a form of congenital disorders of N-linked glycosylation characterized by facial dysmorphism (large, posteriorly rotated ears with prominent antihelices, convex nasal ridge, open mouth, large and crowded teeth), stereotypic hand movements, seizures, and varying degrees of developmental delay. A bleeding tendency is also observed and this results from diminished platelet aggregation. The disease is caused by loss-of-function mutations in the gene <i>MGAT2</i> (14q21).

Disease data
Classification

Disease

Synonyms
CDG syndrome type IIa
CDG2A
CDG-IIa
Niedobór N-acetyloglukozoaminylotransferazy 2
Wrodzone zaburzenie glikozylacji typu 2a
Wrodzone zaburzenie glikozylacji typu IIa
Zespół CDG typu IIa
Zespół obniżonej glikozylacji glikoprotein typu IIa
CDG-IIa
CDG2A
Carbohydrate deficient glycoprotein syndrome type IIa
Congenital disorder of glycosylation type 2a
Congenital disorder of glycosylation type IIa
N-acetylglucosaminyltransferase 2 deficiency
ORPHA code
79329
OMIM code
212066
ICD10 code
E77.8
ICD11 code
-

No additional description.

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