Primary membranoproliferative glomerulonephritis

Orpha code: 54370OMIM code: 615008

Definition

A rare glomerular disease characterized by a pattern of glomerular injury on kidney biopsy with characteristic light microscopic changes: mesangial hypercellularity, endocapillary proliferation, and thickening of the glomerular basement membrane (GBM). On the basis of immunofluorescence (IF) the disorder is divided into C3 glomerulopathy (C3G) or immunoglobulin-mediated membranoproliferative glomerulonephritis. Through electron microscopy C3G is further divided into Dense deposit disease, with highly electrondense deposits in the glomerular basement membrane, and C3 glomerulonephritis, with mesangial, intramembranous, subendothelial and subepithelial deposits. Secondary causes (autoimmune, infectious, malignancies) are excluded.

Disease data
Classification

Disease

Synonyms
Mesangiocapillary glomerulonephritis
Błoniasto-rozplemowe kłębuszkowe zapalenie nerek
MPGN
Primary MPGN
ORPHA code
54370
OMIM code
615008
ICD10 code
N03.5
ICD11 code
GB40

No additional description.

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