Syndromic sensorineural deafness due to combined oxidative phosphorylation defect

Orpha code: 457223OMIM code: 617872

Definition

A rare mitochondrial disease characterized by a variable phenotype comprising congenital sensorineural deafness, intermittent or persistent hypoglycemia, and hepatic and renal dysfunction potentially progressing to organ failure. Serum lactate levels are variably increased, deficiency of mitochondrial respiratory chain complexes I, III, and IV is observed in the liver and in fibroblasts.

Disease data
Classification

Disease

Synonyms
Syndromic sensorineural deafness due to COXPD
Syndromiczna czuciowo-nerwowa głuchota spowodowana COXPD
Syndromiczna czuciowo-nerwowa utrata słuchu spowodowana COXPD
Syndromic sensorineural hearing loss due to COXPD
ORPHA code
457223
OMIM code
617872
ICD10 code
E88.8
ICD11 code
-

No additional description.

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