Autoimmune hemolytic anemia-autoimmune thrombocytopenia-primary immunodeficiency syndrome

Orpha code: 444463OMIM code: 619220

Definition

A rare genetic immune disease characterized by infantile or childhood onset of combined immunodeficiency with recurrent viral, bacterial, and fungal infections, severe autoimmunity mainly manifesting as antibody-mediated destruction of red blood cells, platelets, and neutrophils, and mild to moderate developmental delay. Laboratory findings include decreased circulating T-, B-, and natural killer cells, and hypergammaglobulinemia.

Disease data
Classification

Disease

Synonyms
Evans syndrome associated with primary immunodeficiency
Autoimmunologiczna niedokrwistość hemolityczna i małopłytkowość autoimmunologiczna z pierwotnym niedoborem odporności
Choroba TRIANGLE
Niedobór odporności zależny od TPPII, autoagresja, opóźnienie rozwoju nerwowego z upośledzeniem glikolizy i ekspansą lyzosomów
TPPII deficiency
TPPII-related immunodeficiency, autoimmunity, and neurodevelopmental delay with impaired glycolysis and lysosomal expansion disease
TRIANGLE disease
Tripeptidyl-peptidase II deficiency
ORPHA code
444463
OMIM code
619220
ICD10 code
D89.8
ICD11 code
-

No additional description.

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