Severe phosphoribosylpyrophosphate synthetase superactivity

Orpha code: 411543OMIM code: 300661

Definition

A severe form of phosphoribosylpyrophosphate (PRPP) synthetase superactivity, an X-linked disorder of purine metabolism, characterized by early onset hyperuricemia and hyperuricosuria, and clinically manifesting with urolithiasis, gout and neurodevelopmental anomalies consisting of variable combinations of sensorineural hearing loss, hypotonia, and ataxia.

Disease data
Classification

Clinical subtype

Synonyms
Severe PRPP synthetase superactivity
Ciężka nadczynność PRPS1
Ciężka nadczynność syntetazy PRPP
Severe PRPS1 superactivity
ORPHA code
411543
OMIM code
300661
ICD10 code
E79.8
ICD11 code
-

No additional description.

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