Description of the disease * EnglishPolish Pobierz sekcję do PDF Definition A rare, autosomal dominant neurological disorder due to truncation mutations of the prion protein gene <i>PRNP</i> (20p13) leading to deposition of prion protein amyloid. Onset is usually in the fourth decade of life and reported clinical manifestations include diarrhea, nausea, autonomic failure (areflexia, weakness), neurogenic bladder and urinary infections. Disease data Classification Disease Synonyms Chronic diarrhea with HSAN Przewlekła biegunka z HSAN Chronic diarrhea with hereditary sensory and autonomic neuropathy Prion protein systemic amyloidosis ORPHA code 397606 OMIM code - ICD10 code G60.8 ICD11 code - *Soruce Extended description of the disease Pobierz sekcję do PDF No additional description. Orphanet - interntowa baza danych dotyczących rzadkich chorób i sierochych leków. ©INSERM 1999 - Dostępna na stronie www.orphanet.pl