Description of the disease * EnglishPolish Pobierz sekcję do PDF Definition Hyperostosis corticalis generalisata, also known as van Buchem disease, is a rare craniotubular hyperostosis characterized by hyperostosis of the skull, mandible, clavicles, ribs and diaphyses of the long bones, as well as the tubular bones of the hands and feet. Clinical manifestations include increased skull thickness with cranial nerve entrapment causing inconsistent cranial nerve palsies. Disease data Classification Malformation syndrome Synonyms Hyperphosphatasemia tarda Choroba Van Buchema Hiperfosfatemia późna Van Buchem disease ORPHA code 3416 OMIM code 144750 ICD10 code M85.2 ICD11 code LD24.1Y *Soruce Extended description of the disease Pobierz sekcję do PDF No additional description. Orphanet - interntowa baza danych dotyczących rzadkich chorób i sierochych leków. ©INSERM 1999 - Dostępna na stronie www.orphanet.pl