Spastic paraplegia-Paget disease of bone syndrome

Orpha code: 329475OMIM code:

Definition

Spastic paraplegia-Paget disease of bone syndrome is an extremely rare, complex form of hereditary spastic paraplegia characterized by a slowly progressive spastic paraplegia (with increased muscle tone, decreased strength in the anterior tibial muscles and hyperreflexia in the lower extremities with Babinski sign) presenting in adulthood, associated with Paget disease of the bone. Cognitive decline, dementia and myopathic changes at muscle biopsy have not been reported.

Disease data
Classification

Disease

ORPHA code
329475
OMIM code
-
ICD10 code
G11.4
ICD11 code
-

No additional description.

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