Acute generalized exanthematous pustulosis

Orpha code: 293173OMIM code:

Definicja

A rare hypersensitivity reaction characterized by the rapid development of numerous, nonfollicular, sterile, pinhead-sized pustules on an erythematous base, predominantly occurring on the trunk, intertriginous and flexural areas, with rare, mostly oral, mucosal involvement. Fever, peripheral blood leukocytosis, and mild eosinophilia are accompanying features. Systemic involvement, with hepatic, renal or pulmonary dysfunction, occasionally occurs. Onset usually occurs 1-12 days after administration of the causal medication and is most frequently associated with beta‐lactam antibiotics, macrolides (including pristinamycin and clindamycin), diltiazem, terbinafine, (hydroxy‐)chloroquine but many other medications have also been implicated. Histology reveals spongiform, subcorneal and/or intraepidermal, pustules but this pattern is not specific (same in pustular psoriasis).

Disease data
Klasyfikacja

Disease

Synonimy
AGEP
AGEP
Pustular drug eruption
Toxic pustuloderma
Kod ORPHA
293173
Kod OMIM
-
Kod ICD10
-
Kod ICD11
-

No additional description.

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