Pontocerebellar hypoplasia type 4

Orpha code: 166063OMIM code: 225753

Definition

A severe, genetic form of pontocerebellar hypoplasia (PCH) characterized by delayed neocortical maturation with underdeveloped cerebral hemispheres and pontocerebellar hypoplasia and a severely affected vermis. Clinically, the disorder manifests with prenatal onset of polyhydramnios and contractures followed by hypertonia, severe clonus, primary hypoventilation leading to an early postnatal death.

Disease data
Classification

Malformation syndrome

Synonyms
Hipoplazja oliwkowo-mostowo-móżdżkowa
Fatal infantile encephalopathy with olivopontocerebellar hypoplasia
PCH4
Śmiertelna niemowlęca encefalopatia z hipoplazją oliwkowo-mostowo-móżdżkową
Olivopontocerebellar hypoplasia
PCH4
ORPHA code
166063
OMIM code
225753
ICD10 code
Q04.3
ICD11 code
LD20.01

No additional description.

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