Inherited acute myeloid leukemia

Orpha code: 319465OMIM code: 601626

Definition

Inherited acute myeloid leukemia (AML) is a rare, malignant hematopologic disease characterized by clonal proliferation of myeloid blasts, primarily involving the bone marrow, in association with congenital disorders (e.g. Fanconi anemia, dyskeratosis congenita, Bloom syndrome, Down syndrome, congenital neutropenia, neurofibromatosis, etc.) and genetic defects predisposing to AML. Patients present with signs and symptoms related to ineffective hematopoesis (fatigue, bleeding and bruising, recurrent infections, bone pain) and/or extramedullary site involvement (gingivitis, splenomegaly, etc.). Depending on the underlying genetic defect, there may be additional cancer risks and other health problems present.

Disease data
Classification

Disease

Synonyms
Familial AML
Czysta rodzinna AML
Czysta rodzinna ostra białaczka szpikowa
Dziedziczna AML
Rodzinna AML
Inherited AML
Pure familial AML
Pure familial acute myeloid leukemia
ORPHA code
319465
OMIM code
601626
ICD10 code
C92.0
ICD11 code
-

No additional description.

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