Persistent polyclonal B-cell lymphocytosis

Orpha code: 300324OMIM code: 606445

Definition

Persistent polyclonal B-cell lymphocytosis (PPBL) is a rare, generally benign, lymphoproliferative hematological disease characterized by: chronic, stable, persistent, polyclonal lymphocytosis of memory B-cell origin, the presence of binucleated lymphocytes in the peripheral blood, and a polyclonal increase in serum immunoglobulin M (IgM). Patients are most frequently asymptomatic or may present with mild splenomegaly.

Disease data
Classification

Disease

Synonyms
PPBL
PPBL
Przetrwała poliklonalna limfocytoza B-komórkowa z limfocytami z podwójnym jądrem
Persistent polyclonal B-cell lymphocytosis with binucleated lymphocytes
ORPHA code
300324
OMIM code
606445
ICD10 code
D72.8
ICD11 code
-

No additional description.

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